| Identification | Back Directory | [Name]
GGTI 298 trifluoroacetate salt hydrate | [CAS]
1217457-86-7 | [Synonyms]
GGTI-298 TFA
GGTI 298 TFA salt
GGTI298 Trifluoroacetate
WALKWJPZELDSKT-UFABNHQSSA-N
GGTI 298 trifluoroacetate salt hydrate
GGTI 298 TFA SALT;GGTI 298 (TRIFLUOROACETATE SALT)
N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate | [Molecular Formula]
C29H34F3N3O5S | [MDL Number]
MFCD06409252 | [MOL File]
1217457-86-7.mol | [Molecular Weight]
593.658 |
| Chemical Properties | Back Directory | [Melting point ]
99.5-100°C | [storage temp. ]
-20°C | [solubility ]
DMSO: >20mg/mL | [form ]
film &_& lyophilized | [color ]
colorless | [InChIKey]
WALKWJPZELDSKT-UFABNHQSSA-N | [SMILES]
OC(=O)C(F)(F)F.COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2cccc3ccccc23 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:
- to study the anticancer effects of statins along with GGTI 298
- to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
- to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population
| [Biochem/physiol Actions]
GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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