| Identification | Back Directory | [Name]
Isoderrone | [CAS]
121747-89-5 | [Synonyms]
Isoderrone
5,7-dihydroxy-2',2'-dimethyl-2'H,4H-[3,6'-bichromen]-4-one
3-(2,2-Dimethyl-2H-1-benzopyran-6-yl)-5,7-dihydroxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3-(2,2-dimethyl-2H-1-benzopyran-6-yl)-5,7-dihydroxy- | [Molecular Formula]
C20H16O5 | [MDL Number]
MFCD28100649 | [MOL File]
121747-89-5.mol | [Molecular Weight]
336.34 |
| Chemical Properties | Back Directory | [Boiling point ]
562.1±50.0 °C(Predicted) | [density ]
1.368±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
cryst. | [pka]
6.49±0.20(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Description]
Isoderrone is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 27 ± 7 uM, suggests that it may be a new drug for treatment of type 2 diabetes.
Isoderrone shows inhibitory effects on α-glucosidase in vitro. | [Uses]
Isoderrone is a new isoflavone isolated from the methanol extractives from white lupin (cv. Kievskij Mutant) roots[1]. | [Definition]
ChEBI: Isoderrone is a hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5 and 7 and a 6,6-dimethyl-3,6-dihydro-2H-pyran across positions 3' and 4' respectively. It has been isolated from Ficus mucuso. It has a role as a plant metabolite. It is functionally related to an isoflavone. | [target]
Tyrosinase | [References]
[1] Satoshi Tahara, et, al. Seventeen isoflavonoids from Lupinus albus roots. Phytochemistry. 1998, 28, 3. |
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