| Identification | Back Directory | [Name]
(-)-Ibuprofenamide | [CAS]
121839-78-9 | [Synonyms]
(-)-Ibuprofemide
(R)-Ibuprofenamide
(-)-Ibuprofenamide | [Molecular Formula]
C13H17NO3 | [MDL Number]
MFCD32062744 | [MOL File]
121839-78-9.mol | [Molecular Weight]
235.279 |
| Hazard Information | Back Directory | [Uses]
(-)-Ibuprofenamide is an amide proagent of Ibuprofen with anti-inflammatory activity[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[2]. | [References]
[1] Shanbhag VR, et al. Ester and amide prodrugs of ibuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity. J Pharm Sci. 1992 Feb;81(2):149-54. DOI:10.1002/jps.2600810210
[2] Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. DOI:10.1021/np970343j |
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