| Identification | Back Directory | [Name]
TETRANOR-12(S)-HETE | [CAS]
121842-79-3 | [Synonyms]
TETRANOR-12(S)-HETE
KBOVKDIBOBQLRS-ONCCEEIJSA-N
4,6,10-Hexadecatrienoic acid, 8-hydroxy-, [S-(E,Z,Z)]- (9CI) | [Molecular Formula]
C16H26O3 | [MDL Number]
MFCD08457913 | [MOL File]
121842-79-3.mol | [Molecular Weight]
266.38 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .5 mg/ml |
| Hazard Information | Back Directory | [Description]
12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger’s Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound. | [Uses]
Tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE (HY-124404A) in numerous tissues. 12(S)‐HETE to tetranor‐12(S)‐HETE conversion could be a marker for psoriasis[1]. | [Definition]
ChEBI: Tetranor 12-HETE is a hydroxy fatty acid. | [References]
[1] Setkowicz M, et al. Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. Br J Dermatol. 2015 Feb;172(2):337-44. DOI:10.1111/bjd.13225 |
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