| Identification | Back Directory | [Name]
(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE | [CAS]
1218935-60-4 | [Synonyms]
(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HCL
(R)-2-(2,5-Difluorophenyl)pyrrolidene hydrochloride
(R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HYDROCHLORIDE
Pyrrolidine, 2-(2,5-difluorophenyl)-, hydrochloride (1:1), (2R)- | [EINECS(EC#)]
-0 | [Molecular Formula]
C10H12ClF2N | [MDL Number]
MFCD08751413 | [MOL File]
1218935-60-4.mol | [Molecular Weight]
219.66 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
Off-white to light yellow Solid | [InChI]
InChI=1/C10H11F2N.ClH/c11-7-3-4-9(12)8(6-7)10-2-1-5-13-10;/h3-4,6,10,13H,1-2,5H2;1H/t10-;/s3 | [InChIKey]
XSWCQOVADZHFIJ-MEQOOBBNNA-N | [SMILES]
FC1C=CC(F)=CC=1[C@@H]1NCCC1.Cl |&1:8,r| |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of (R)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride from the compound (CAS: 1443538-31-5) was as follows: to a stirred solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (15 g, 52.19 mmol) in dioxane (25 mL) was added a 4 M HCl to a solution of dioxane (75 mL). The reaction mixture was stirred continuously at 20-35°C for 4 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by washing with ether to give 7.5 g of (R)-2-(2,5-difluorophenyl)pyrrolidine hydrochloride as a white solid. Mass spectrometry (ESI) analysis showed: m/z 184 (M + H). | [References]
[1] Patent: WO2013/88256, 2013, A1. Location in patent: Page/Page column 59
[2] Patent: US2014/371217, 2014, A1. Location in patent: Paragraph 0561
[3] Patent: US2015/5280, 2015, A1. Location in patent: Paragraph 0527 - 0529
[4] Patent: US2015/368238, 2015, A1. Location in patent: Paragraph 0574; 0579 |
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