| Identification | Back Directory | [Name]
17-phenyl trinor Prostaglandin E2 ethyl amide | [CAS]
1219032-20-8 | [Synonyms]
17-phenyl trinor Prostaglandin E2 ethyl amide
17-phenyl trinor Prostaglandin E2 ethyl amide Exclusive
(Z)-N-ethyl-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamide
5-Heptenamide, N-ethyl-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-5-oxocyclopentyl]-, (5Z)- | [Molecular Formula]
C25H35NO4 | [MOL File]
1219032-20-8.mol | [Molecular Weight]
413.55 |
| Chemical Properties | Back Directory | [Boiling point ]
629.4±55.0 °C(Predicted) | [density ]
1.141±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [pka]
13.78±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) is a EP1 receptor agonist. 17-Phenyl trinor prostaglandin E2 ethyl amide aggravates renal dysfunction and glomerulosclerosis[1]. | [in vivo]
17-Phenyl trinor prostaglandin E2 ethyl amide (0.3 μg/g; i.p.; three times a week for 12 weeks) aggravates renal dysfunction and glomerulosclerosis in five?sixths nephrectomy renal fibrosis model mice[1]. | Animal Model: | 8-12 weeks, 15-20 g, C57/BL6 male mice (five?sixths nephrectomy renal fibrosis model)[1] | | Dosage: | 0.3 μg/g | | Administration: | I.p.; three times a week for 12 weeks | | Result: | Increased the plasma blood urea nitrogen (BUN) levels and plasma creatinine (Cr) concentration, increased the extracellular matrix and the area of collagen deposition, upregulated the protein of expression of Col1, GRP78, TRPC1 and PERK in 5/6 Nx mice. |
| [storage]
Store at -20°C | [References]
[1] Chen X, et al. Effect of selective inhibition or activation of PGE2 EP1 receptor on glomerulosclerosis. Mol Med Rep. 2020 Oct;22(4):2887-2895. DOI:10.3892/mmr.2020.11353 |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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