| Identification | Back Directory | [Name]
BC-1293 | [CAS]
1219395-86-4 | [Synonyms]
BC-1293
Benzenesulfonamide, 5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-N-[2-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)-1-methyl-2-oxoethyl]-2-methyl- | [MOL File]
1219395-86-4.mol | [Molecular Weight]
492.59 |
| Chemical Properties | Back Directory | [Boiling point ]
719.384±70.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.314±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
9.908±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
BC-1293 is an inhibitor for E3 ligase subunit FBXO24. BC-1293 disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) and increases the level of DARS2. BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, and exhibits immunostimulatory activity in mice[1]. | [References]
[1] Johnson BS, et al., Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses. Nat Commun. 2024 Jul 22;15(1):6172. DOI:10.1038/s41467-024-50031-7 |
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