| Identification | Back Directory | [Name]
N-(3-acetylphenyl)-4,5-dimethyl-2-(tetrazol-1-yl)thiophene-3-carboxamide | [CAS]
1219576-50-7 | [Synonyms]
CREBBPIN9
CREBBP-IN-9
CREBBP IN 9
N-(3-acetylphenyl)-4,5-dimethyl-2-(tetrazol-1-yl)thiophene-3-carboxamide
3-Thiophenecarboxamide, N-(3-acetylphenyl)-4,5-dimethyl-2-(1H-tetrazol-1-yl)- | [Molecular Formula]
C16H15N5O2S | [MOL File]
1219576-50-7.mol | [Molecular Weight]
341.39 |
| Hazard Information | Back Directory | [Description]
CREBBP-IN-9 is a CREBBP inhibitor that acts on the bromodomain of the protein. | [Uses]
CREBBP-IN-9 (Compound 9) is an inhibitor for CREBBP with an Kd of 29 μM[1]. | [References]
[1] Xu M, et al., Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics. J Med Chem. 2016 Feb 25;59(4):1340-9. DOI:10.1021/acs.jmedchem.5b00171 |
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