| Identification | Back Directory | [Name]
AMPK activator 991 | [CAS]
1219739-95-3 | [Synonyms]
AMPK-IN-1
AMPK activator 991
Benzoic acid, 5-[[6-chloro-5-(1-methyl-1H-indol-6-yl)-1H-benzimidazol-2-yl]oxy]-2-methyl- | [Molecular Formula]
C24H18ClN3O3 | [MOL File]
1219739-95-3.mol | [Molecular Weight]
431.87 |
| Chemical Properties | Back Directory | [Boiling point ]
706.4±70.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.40±0.25(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way[1][2][3]. | [IC 50]
AMPK α2β2γ1: 551 nM (EC50) | [References]
[1] Ngoei KRW, et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. DOI:10.1016/j.chembiol.2018.03.008
[2] Cao Y, et al. Novel cyclic benzimidazole derivatives useful anti-diabetic agents. Patent. WO2010036613.
[3] Johanns M, et al. Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cell Signal. 2017 Aug;36:212-221. DOI:10.1016/j.cellsig.2017.05.010 |
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