| Identification | Back Directory | [Name]
1H-Pyrazole-1-ethanol, 4-[9-hydroxy-2-methyl-9-(trifluoromethyl)-9H-fluoren-4-yl]- | [CAS]
1220965-73-0 | [Synonyms]
1H-Pyrazole-1-ethanol, 4-[9-hydroxy-2-methyl-9-(trifluoromethyl)-9H-fluoren-4-yl]- | [Molecular Formula]
C20H17F3N2O2 | [MOL File]
1220965-73-0.mol | [Molecular Weight]
374.36 |
| Hazard Information | Back Directory | [Uses]
PDHK-IN-7 (compound 32) is an inhibitor of pyruvate dehydrogenase kinase with an IC50 value of 17 nM.PDHK-IN-7 activates PDH in rat livers and has a glucose-lowering effect in Zucker fatty rats[1]. | [References]
[1] Masafumi Inoue, et al. Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg Med Chem Lett. 2024 Sep 1:109:129839. DOI:10.1016/j.bmcl.2024.129839 |
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