| Hazard Information | Back Directory | [Description]
YQA14 is a selective D3 receptor antagonist. | [Uses]
YQA14 is a high affinity dopamine D3 receptor antagonist. YQA14 is anti-opioid addiction agent. YQA14 inhibits Morphine/Cocaine-induced conditioned place preference (CPP) in animals[1][2]. | [References]
[1] Hu R, et al. The dopamine D3 receptor antagonist YQA14 that inhibits the expression and drug-primed reactivation of morphine-induced conditioned place preference in rats. Eur J Pharmacol. 2013 Oct 24:S0014-2999(13)00782-6. DOI:10.1016/j.ejphar.2013.10.026
[2] Song R, et al. Dopamine D(3) receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice. Neuropharmacology. 2013 Sep;72:82-7. DOI:10.1016/j.neuropharm.2013.04.042 |
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Merck KGaA
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