| Identification | Back Directory | [Name]
CASPASE-1 | [CAS]
122191-40-6 | [Synonyms]
ICE
CASP-1
IL-1BC
CASPASE-1
ICE 1B HUMAN
P45) USP/EP/BP
CASPASE 1 HUMAN
IL-1 β converting enzyme
IL-1BETA CONVERTING ENZYME
Interleukin-1β-Converting Enzyme
INTERLEUKIN-1BETA CONVERTING ENZYME
CASPASE-1 HUMAN, RECOMBINANT, ACTIVE
CASPASE-1, HUMAN, RECOMBINANT, E COLI
INTERLEUKIN-1B-CONVERTING ENZYME HUMAN
ICE, Interleukin-1β-Converting Enzyme
CASPASE-1 PROTEIN, RECOMBINANT HUMAN ACTIVE
Anti-CASP1, C-Terminal antibody produced in rabbit
Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit
Anti-CASP1 (p20, Cleaved-Asn120) antibody produced in rabbit | [MDL Number]
MFCD02677921 |
| Hazard Information | Back Directory | [Uses]
Caspase 1 human has been used in in vitro cleavage assay with Rab interacting lysosomal protein (RILP) and in the cleavage of caspases-3/7 in human monocytic?cells (THP1). | [General Description]
Caspase 1, also called interleukin (IL)-1-converting enzyme, is mapped to human 11q22.3. It belongs to the aspartate-specific cysteine proteases family and is primarily synthesized as procaspase-1 zymogen, which later become catalytically active post autoproteolysis. The enzymatically active caspase-1 comprises two p20/p10 heterodimer making it a tetramer. | [Biochem/physiol Actions]
Caspase 1 catalyzes the conversion of pro-inflammatory cytokine, pro-interleukin (IL)-1β to its active form. It has broad substrate specificity and is an apoptosis regulator. Caspase-1 is indirectly implicated in the pathology of cryopyrin-associated periodic syndrome (CAPS). It is a multiple inflammasome-associated protein associated with multiple sclerosis (MS) lesions and is a prime target for inhibitor screening. |
|
|