| Identification | Back Directory | [Name]
PS315 | [CAS]
1221964-50-6 | [Synonyms]
PS315
(Z)-3-(4-Biphenylyl)-5-(4-chlorophenyl)-2-pentenoic Acid | [Molecular Formula]
C23H19ClO2 | [MDL Number]
MFCD32671335 | [MOL File]
1221964-50-6.mol | [Molecular Weight]
362.85 |
| Hazard Information | Back Directory | [Description]
PS315 is an allosteric atypical protein kinase C (aPKC) inhibitor that acts by binding to the PIF-pocket. | [Uses]
PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity[1]. | [IC 50]
PKCζ: 10 μM (IC50); PKCη: 30 μM (IC50) | [References]
[1] Zhang H, et al. Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound. Chem Biol. 2014 Jun 19;21(6):754-65. DOI:10.1016/j.chembiol.2014.04.007 |
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