| Identification | Back Directory | [Name]
9-(6-Amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one | [CAS]
1223002-54-7 | [Synonyms]
QL-IX-55
QL-IX-55;QL IX 55;QLIX55
9-(6-Amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one
Benzo[h]-1,6-naphthyridin-2(1H)-one, 9-(6-amino-3-pyridinyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C24H14F4N4O | [MDL Number]
MFCD22417089 | [MOL File]
1223002-54-7.mol | [Molecular Weight]
450.388 |
| Chemical Properties | Back Directory | [Boiling point ]
640.3±55.0 °C(Predicted) | [density ]
1.466 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO | [form ]
Powder | [pka]
5.66±0.26(Predicted) |
| Hazard Information | Back Directory | [Uses]
QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively. | [References]
[1] Akiyoshi-Shibata M, et al. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli. Eur J Biochem. 1994 Sep 1;224(2):335-43. DOI:10.1111/j.1432-1033.1994.00335.x |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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