| Identification | Back Directory | [Name]
(R)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide | [CAS]
1223404-68-9 | [Synonyms]
Larotrectinib impurity
Larotrectinib Impurity 8
Larotrectinib Impurity 2
Larotrectinib Impurity 7
(R)-N-(2-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrrolo[1,2-a]pyrimidin-8-yl)-3-hydroxypyrrolidine-1-carboxamide
(R)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide | [Molecular Formula]
C21H22F2N6O2 | [MOL File]
1223404-68-9.mol | [Molecular Weight]
428.44 |
| Hazard Information | Back Directory | [Uses]
(R)-Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases[1] | [IC 50]
TrkA: 28.5 nM (IC50) | [References]
[1] Julia Haas, et al. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS. WO2010048314A1 (compound 93) |
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TaiChem Taizhou Limited
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052386810091 |
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https://www.chemicalbook.com/supplier/11410902/1.htm |
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