| Identification | Back Directory | [Name]
Etoposide phosphate disodium | [CAS]
122405-33-8 | [Synonyms]
Etoposide phosphate disodium | [Molecular Formula]
C29H34NaO16P | [MDL Number]
MFCD00896435 | [MOL File]
122405-33-8.mol | [Molecular Weight]
692.54 |
| Hazard Information | Back Directory | [Uses]
Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy. | [in vivo]
Etoposide phosphate (intravenous injection; 50, 100, or 150 mg/kg; single dose) has clinical symptomology of progressive ataxia, impaired righting reflex, and splaying and paresis of fore- and hindlimbs at day 8?in female CD-1 mice[3]. | Animal Model: | Female CD-1 mice[3] | | Dosage: | 50, 100, or 150 mg/kg | | Administration: | Intravenous injection; single dose | | Result: | Observed degeneration of dorsal root ganglion cells and axonal degeneration of their distal and proximal processes in peripheral nerves, dorsal spinal roots, and dorsal funiculi of the spinal cord at all doses under light microscopy (LM). |
| [IC 50]
Topoisomerase II | [References]
[1] Witterland AH, et al. Etoposide phosphate, the?water?soluble?prodrug?of?etoposide. Pharm World Sci.?1996 Oct;18(5):163-70. DOI:10.1007/BF00820727
[2] Cui D, et al. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.Cell Rep.?2020 Jan 14;30(2):497-509.e4. DOI:10.1016/j.celrep.2019.12.032
[3] Bregman CL, et al. Etoposide- and BMY-40481-induced sensory neuropathy in mice.Toxicol Pathol.?1994 Sep-Oct;22(5):528-35. DOI:10.1177/019262339402200508
[4] SUMMARY OF PRODUCT CHARACTERISTICS |
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