| Identification | Back Directory | [Name]
(S)-AL 8810 | [CAS]
1224444-55-6 | [Synonyms]
(S)-AL 8810
WTYSXBKKVNOOIX-KSKLXAOMSA-N
9ALPHA,15S-DIHYDROXY-11BETA-FLUORO-15-(2,3-DIHYDRO-1H-INDEN-2-YL)-16,17,18, 19,20-PENTANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID | [Molecular Formula]
C24H31FO4 | [MDL Number]
MFCD05863928 | [MOL File]
1224444-55-6.mol | [Molecular Weight]
402.5 |
| Chemical Properties | Back Directory | [Boiling point ]
594.6±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: miscible; PBS (pH 7.2): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the inverse, (S), or “natural” configuration at C-15 relative to AL 8810, which is 15-(R). The pharmacology of (S)-AL 8810 has not been published. | [Uses]
(S)-AL 8810 is an 11β-fluoro analog of PGF2α that acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the
inverse, (S), or "natural" configuration at C-15 relative to AL 8810, which is 15-(R)[1]. | [Definition]
ChEBI: 5-heptenoic acid, 7-[(1r,2r,3s,5s)-2-[(1e,3s)-3-(2,3-dihydro-1h-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5z)- is a long-chain fatty acid. | [References]
[1] Griffin BW, Klimko P, Crider JY, Sharif NA. AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84. PMID:10454504 |
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