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1224567-46-7

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1224567-46-7 Structure

1224567-46-7 Structure
IdentificationBack Directory
[Name]

653-47
[CAS]

1224567-46-7
[Synonyms]

653-47
653-47 hydrochloride
[Molecular Formula]

C20H20Cl2N2O3
[MOL File]

1224567-46-7.mol
[Molecular Weight]

407.29
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 250 mg/mL (613.81 mM; Need ultrasonic)
[form ]

Solid
[color ]

Pale purple to purple
Hazard InformationBack Directory
[Uses]

653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
[References]

[1] Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429. DOI:10.1021/acs.jmedchem.9b01207
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