| Identification | Back Directory | [Name]
2-Naphthalenecarboxamide, 3-(3-aminopropoxy)-N-(4-chloro-2-hydroxyphenyl)- | [CAS]
1224678-75-4 | [Synonyms]
2-Naphthalenecarboxamide, 3-(3-aminopropoxy)-N-(4-chloro-2-hydroxyphenyl)- | [Molecular Formula]
C20H19ClN2O3 | [MDL Number]
MFCD34471109 | [MOL File]
1224678-75-4.mol | [Molecular Weight]
370.83 |
| Chemical Properties | Back Directory | [Boiling point ]
516.1±50.0 °C(Predicted) | [density ]
1.355±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [pka]
8.20±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1]. | [References]
[1] Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429. DOI:10.1021/acs.jmedchem.9b01207 |
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