| Identification | Back Directory | [Name]
GLP-1 (28-36)amide | [CAS]
1225021-13-5 | [Synonyms]
GLP-1 (28-36)amide
L-Argininamide, L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl- | [Molecular Formula]
C54H85N15O9 | [MDL Number]
MFCD33023595 | [MOL File]
1225021-13-5.mol | [Molecular Weight]
1088.35 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [form ]
Solid | [pka]
13.30±0.46(Predicted) | [color ]
White to off-white | [Sequence]
Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 |
| Hazard Information | Back Directory | [Uses]
GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide has anti-diabetic and cardioprotection effects[1]. | [in vivo]
The administration of GLP-1(28-36)amide at a rate of 18.5 nmol/kg BW/day for 9 weeks to diet-induced obese mice diminishes the development of hepatic steatosis[1].
The intraperitoneal injection of 18 nmol/kg GLP-1(28-36)amide once daily for 9 weeks show cytoprotective effect on pancreatic β cells by increasing mass and promoting proliferation in a β-cell injury diabetic mouse model[1].
An in vivo study in high-fat diet-fed mice indicates that a six-week administration of 18.5 nmol/kg GLP-1(28-36)amide improved hepatic glucose disposal, which is associated with increased cAMP levels and phosphorylation of PKA target[1].
Administered GLP-1(28-36)amide for 20 min to male C57BL6/J mice (10-12 week old), then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure (LVDP) is significantly greater in GLP-1(28-36)amide group compared to vehicle-treated hearts[1]. | [storage]
-20°C, protect from light | [References]
[1] Bilan Zhou, et al. GLP-1(28-36)amide, a Long Ignored Peptide Revisited. Open Biochem J. 2014 Dec 31;8:107-11. DOI:10.2174/1874091X01408010107 |
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Combio (Suzhou) Ltd.
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17751201929; 17751201929 |
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http://www.combiosz.com/ |
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YantaiBio
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13758194781; 13758194781 |
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