| Identification | Back Directory | [Name]
Cefiderocol | [CAS]
1225208-94-5 | [Synonyms]
Cefiderocol
(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((1-(2-(2-chloro-3,4-dihydroxybenzamido)ethyl)pyrrolidin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | [Molecular Formula]
C30H34ClN7O10S2 | [MDL Number]
MFCD30533432 | [MOL File]
1225208-94-5.mol | [Molecular Weight]
752.21 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C, stored under nitrogen,unstable in solution, ready to use. | [solubility ]
DMSO:50.0(Max Conc. mg/mL);66.47(Max Conc. mM) | [form ]
Solid | [color ]
White to off-white | [InChIKey]
DBPPRLRVDVJOCL-OLKYWZQRNA-N | [SMILES]
C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC(C)(C)C(=O)O)C(=O)N12)C[N+]1(CCCC1)CCNC(C1C=CC(O)=C(O)C=1Cl)=O)(=O)[O-] |&1:5,7,r| |
| Hazard Information | Back Directory | [Uses]
Cefiderocol, is a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, that has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, | [reaction suitability]
reagent type: chelator | [Pharmaceutical Applications]
Cefiderocol can be used for the treatment of complicated urinary tract infections (cUTIs) when other treatment options are limited or nonexistent. | [Biological Activity]
Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wallleading to cell lysis and bacterial death.
Antimicrobial Spectrum: Cefiderocol has strong antimicrobial propertiesespecially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelatorwhich adds to its antibacterial activities. | [Synthesis]
Below shows the synthesis route of Cefiderocol
| [IC 50]
β-lactam |
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| Company Name: |
TaiChem Taizhou Limited
|
| Tel: |
052386810091 |
| Website: |
https://www.chemicalbook.com/supplier/11410902/1.htm |
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