| Identification | Back Directory | [Name]
citreamicin alpha | [CAS]
122535-63-1 | [Synonyms]
LL-E-19085α
Citreamicin α
LL-E19085alpha
citreamicin alpha
3-Methylbutanoic acid [(1,2,8,14,15,17-hexahydro-16-hydroxy-11,12-dimethoxy-1,1-dimethyl-2,8,14,15,17-pentaoxo[1]benzopyrano[2',3':6,7]naphth[2,1-g]oxazolo[3,2-b]isoquinolin)-3a(4H)-yl]methyl ester | [Molecular Formula]
C36H31NO12 | [MDL Number]
MFCD00877048 | [MOL File]
122535-63-1.mol | [Molecular Weight]
669.636 |
| Hazard Information | Back Directory | [Description]
Citreamicin alpha is an antibacterial agent isolated from Micromonospora citrea. | [Uses]
Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin. | [References]
[1] Antibacterial activity of citreamicin-alpha (LL-E 19085 alpha) against gram-positive cocci |
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