| Identification | Back Directory | [Name]
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- | [CAS]
1226549-39-8 | [Synonyms]
EGFR-IN-9
EGFRIN9,EGFR IN 9
N-{3-[4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]-pyrimidin-5-yl]phenyl}acrylamide
N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide
2-PropenaMide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]aMino]-6-phenylfuro[2,3-d]pyriMidin-5-yl]phenyl]- | [Molecular Formula]
C29H24N4O3 | [MDL Number]
MFCD25977045 | [MOL File]
1226549-39-8.mol | [Molecular Weight]
476.526 |
| Chemical Properties | Back Directory | [Boiling point ]
719.0±60.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (209.85 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.24±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity[1]. | [IC 50]
EGFR (WT): 7 nM (IC50); EGFRL858R/T790M: 28 nM (IC50) | [References]
[1] Coumar MS, et al. Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor leadidentification. J Med Chem. 2010 Jul 8;53(13):4980-8. DOI:10.1021/jm1000198 |
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