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1226917-67-4

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1226917-67-4 Structure

1226917-67-4 Structure
IdentificationBack Directory
[Name]

SB 277011A dihydrochloride
[CAS]

1226917-67-4
[Synonyms]

SB 277011-A 2HCL
SB-277011 dihydrochloride
SB 277011A dihydrochloride
SB277011 dihydrochloride,SB 277011 dihydrochloride
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
N-((1R,4r)-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide dihydrochloride
[Molecular Formula]

C28H30N4O.2HCl
[MDL Number]

MFCD16627999
[MOL File]

1226917-67-4.mol
[Molecular Weight]

475.03
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble to 5 mM in water and to 50 mM in DMSO
[form ]

Powder
[color ]

white
[Water Solubility ]

water: 100mM
[InChIKey]

HEZIOTGUXSPDAK-ONAIBGCWSA-N
[SMILES]

Cl.Cl.N4(CCc5c(ccc(c5)C#N)C4)CC[C@@H]1CC[C@H](CC1)NC(=O)c2c3c(ncc2)cccc3
Safety DataBack Directory
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

SB 277011A Dihydrochloride is a selective dopamine D3 receptor antagonist and brain penetrant.
[Biological Activity]

Primary Target
D3
[in vivo]

SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.) completely reverses the effects of quinelorane in the nucleus accumbens, but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats[1].SB-277011A (intraperitoneal injection; 12.5-25 mg/kg) significantly and dose-dependently inhibits self-administration in rats. When it increases to 50 mg/kg, SB-277011A can significantly inhibit basal and addictive agent-enhanced locomotion in rats[2].

[IC 50]

D3 Receptor
[storage]

Store at +4°C
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