| Identification | Back Directory | [Name]
SB 277011A dihydrochloride | [CAS]
1226917-67-4 | [Synonyms]
SB 277011-A 2HCL
SB-277011 dihydrochloride
SB 277011A dihydrochloride
SB277011 dihydrochloride,SB 277011 dihydrochloride
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
N-((1R,4r)-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide dihydrochloride | [Molecular Formula]
C28H30N4O.2HCl | [MDL Number]
MFCD16627999 | [MOL File]
1226917-67-4.mol | [Molecular Weight]
475.03 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 5 mM in water and to 50 mM in DMSO | [form ]
Powder | [color ]
white | [Water Solubility ]
water: 100mM | [InChIKey]
HEZIOTGUXSPDAK-ONAIBGCWSA-N | [SMILES]
Cl.Cl.N4(CCc5c(ccc(c5)C#N)C4)CC[C@@H]1CC[C@H](CC1)NC(=O)c2c3c(ncc2)cccc3 |
| Hazard Information | Back Directory | [Uses]
SB 277011A Dihydrochloride is a selective dopamine D3 receptor antagonist and brain penetrant. | [Biological Activity]
Primary Target
D3 | [in vivo]
SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.) completely reverses the effects of quinelorane in the nucleus accumbens, but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats[1].SB-277011A (intraperitoneal injection; 12.5-25 mg/kg) significantly and dose-dependently inhibits self-administration in rats. When it increases to 50 mg/kg, SB-277011A can significantly inhibit basal and addictive agent-enhanced locomotion in rats[2]. | [IC 50]
D3 Receptor | [storage]
Store at +4°C |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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