| Identification | Back Directory | [Name]
1-(3-chlorobenzyl)-3-hydroxy-3-[2-oxo-2-(2-pyridinyl)ethyl]-1,3-dihydro-2H-indol-2-one | [CAS]
1227045-76-2 | [Synonyms]
AK-778-XXMU
1-(3-chlorobenzyl)-3-hydroxy-3-[2-oxo-2-(2-pyridinyl)ethyl]-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 1-[(3-chlorophenyl)methyl]-1,3-dihydro-3-hydroxy-3-[2-oxo-2-(2-pyridinyl)ethyl]- | [Molecular Formula]
C22H17ClN2O3 | [MOL File]
1227045-76-2.mol | [Molecular Weight]
392.83 |
| Chemical Properties | Back Directory | [Boiling point ]
664.4±55.0 °C(Predicted) | [density ]
1.393±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.83±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
AK-778-XXMU is a potent inhibitor of DNA Binding 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down the tumor growth[1]. | [References]
[1] Zhong G, et al. Discovery of novel ID2 antagonists from pharmacophore-based virtual screening as potential therapeutics for glioma. Bioorg Med Chem. 2021;49:116427. DOI:10.1016/j.bmc.2021.116427 |
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