| Identification | Back Directory | [Name]
1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone | [CAS]
1227067-61-9 | [Synonyms]
1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone
Ethanone, 1-[4-[3-[4-(1H-benzimidazol-2-ylcarbonyl)phenoxy]-2-pyrazinyl]-1-piperidinyl]- | [Molecular Formula]
C25H23N5O3 | [MOL File]
1227067-61-9.mol | [Molecular Weight]
441.48 |
| Chemical Properties | Back Directory | [Boiling point ]
689.9±65.0 °C(Predicted) | [density ]
1.322±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 41.67 mg/mL (94.39 mM) | [form ]
Solid | [pka]
10.10±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. | [in vivo]
AMG 579 shows statistically significant reduction of PCP induced behavior in rats over the 2 h period. Minimum effective doses for efficacy in PCP-LMA model is determined to be 0.3 mg/kg for AMG 579. In dog, 5 exhibits superior oral bioavailability of 72%[1]. | [storage]
Store at -20°C | [References]
[1] Hu E,et al. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). J Med Chem. 2014 Aug 14;57(15 DOI:10.1021/jm500713j |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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