| Identification | Back Directory | [Name]
1H-Isoindol-3-amine, 4-fluoro-1-[4-fluoro-3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-, (1S)- | [CAS]
1227163-49-6 | [Synonyms]
AZD3289
AZD-3289
AZD 3289
1H-Isoindol-3-amine, 4-fluoro-1-[4-fluoro-3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-, (1S)- | [Molecular Formula]
C24H14F5N5 | [MOL File]
1227163-49-6.mol | [Molecular Weight]
467.39 |
| Hazard Information | Back Directory | [Description]
AZD-3289 is a potent BACE1 inhibitor potentially for the treatment of Alzheimer's disease. | [Uses]
AZD-3289 is a potent BACE1 inhibitor with potential Alzheimer's disease inhibitory activity. The application of AZD-3289 is intended to slow the pathological progression of Alzheimer's disease by inhibiting the production of β-amyloid protein. The development of AZD-3289 responds to the need to reduce neurodegenerative changes associated with Alzheimer's disease. As a BACE1 inhibitor, AZD-3289 can effectively reduce the accumulation of β-amyloid peptide in the brain, which may improve cognitive function[1]. | [References]
[1] Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs DOI:10.1186/s40035-016-0061-5 |
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