1227177-68-5

1065010-87-8

113975-22-7

1227177-68-5

2-Fluoro-3-iodopyridine (300 mg, 1.34 mmol), potassium cyclopropyltrifluoroborate (498 mg, 3.36 mmol) and palladium(II) acetate (30 mg, 0.135 mmol) were dissolved in toluene (4 mL) under nitrogen protection. Tricyclohexylphosphine (75 mg, 0.27 mmol), tripotassium phosphate (1.1 g, 5.38 mmol) and water (0.4 mL) were then added. The reaction mixture was placed in a microwave reactor and heated at 130 °C for 2 hours. After completion of the reaction, it was cooled to room temperature, water was added and the aqueous layer was extracted with dichloromethane (DCM). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, and concentrated to give 3-cyclopropyl-2-fluoropyridine (200 mg, 97% yield). UPLC-MS (Method 2): retention time (R) = 0.94 min; MS (ESI positive ion mode): m/z = 138 ([M + H]+).