| Identification | Back Directory | [Name]
Closthioamide | [CAS]
1227367-59-0 | [Synonyms]
Closthioamide
β-Alaninamide, 2,2'-(1,3-propanediyl)bis[N-[(4-hydroxyphenyl)thioxomethyl]thio-β-alanylthio- | [Molecular Formula]
C29H38N6O2S6 | [MDL Number]
MFCD30747892 | [MOL File]
1227367-59-0.mol | [Molecular Weight]
695.02 |
| Chemical Properties | Back Directory | [Melting point ]
162-168 °C | [Boiling point ]
857.0±75.0 °C(Predicted) | [density ]
1.353±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
8.59±0.15(Predicted) |
| Hazard Information | Back Directory | [Uses]
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against Ec, MRSA, VRE and Mv), with MICs of 9.00 μM, 0.58 μM, 0.58 μM and 72.03 μM respectively. | [References]
[1] Chiriac AI, et al. Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors. J AntimicrobChemother. 2015Sep;70(9):2576-88. DOI:10.1093/jac/dkv161
[2] Lincke T, et al. Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum.Angew Chem Int Ed Engl. 2010 Mar 8;49(11):2011-3. DOI:10.1002/anie.200906114 |
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