| Identification | Back Directory | [Name]
2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- | [CAS]
1227827-88-4 | [Synonyms]
EP3 antagonist 3
2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- | [Molecular Formula]
C21H18N2O4 | [MOL File]
1227827-88-4.mol | [Molecular Weight]
362.38 |
| Chemical Properties | Back Directory | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (689.88 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.09±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research[1]. | [IC 50]
EP3: 8.3 (pKi) | [References]
[1] Jin J, et al. Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1(7):316-20. DOI:10.1021/ml100077x |
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