| Identification | Back Directory | [Name]
4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester | [CAS]
1228689-61-9 | [Synonyms]
methyl 5-(4-bromophenyl)-3-methyl-isoxazole-4-carboxylate
4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester | [Molecular Formula]
C12H10BrNO3 | [MDL Number]
MFCD18384841 | [MOL File]
1228689-61-9.mol | [Molecular Weight]
296.12 |
| Chemical Properties | Back Directory | [Boiling point ]
403.9±45.0 °C(Predicted) | [density ]
1.472±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
-4.39±0.50(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
To a stirred solution of methyl 2-(4-bromobenzoyl)-3-(methylamino)but-2-enoate (0.78 g, 2.5 mmol) in acetic acid (10 mL) was added hydroxylamine hydrochloride (0.17 g, 2.5 mmol) under nitrogen atmosphere. After addition, the reaction mixture was heated to reflux for 2 hours under nitrogen protection. Upon completion of the reaction, the mixture was concentrated under reduced pressure to afford the crude product methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate (0.66 g, 89% yield), which could be used for subsequent reactions without further purification. | [References]
[1] Patent: WO2013/25733, 2013, A1. Location in patent: Paragraph 0404 |
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Energy Chemical
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Synthonix Inc
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www.synthonix.com |
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A.J Chemicals
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