| Identification | Back Directory | [Name]
DIHYDREXIDINE HYDROCHLORIDE | [CAS]
123039-93-0 | [Synonyms]
DAR-0100
DihydrexidineHCl
Dihydrexidine hydroc
DIHYDROXIDINE HYDROCHLORIDE
DIHYDREXIDINE HYDROCHLORIDE
Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, (6aR,12bS)-rel-
(+/-)-TRANS-10,11-DIHYDROXY-5,6,6A,7,8,12B-HEXAHYDROBENZO[A]PHENANTHRIDINE HYDROCHLORIDE | [Molecular Formula]
C17H17NO2 | [MDL Number]
MFCD01860859 | [MOL File]
123039-93-0.mol | [Molecular Weight]
267.32 |
| Hazard Information | Back Directory | [Uses]
Dihydrexidine is a moderately selective full agonist at the dopamine D1 and D5 receptors (1,2). It has been shown to have antiparkinson effects. It also has the ability to improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder. | [Biological Activity]
A potent, full efficacy dopamine D 1 agonist which shows no agonist activity at peripheral D 2 receptors or adrenoceptors at doses which cause maximal stimulation of D 1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo . | [in vivo]
Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].
| Animal Model: | Adult male Sprague–Dawley rats (275-300 g)[4] | | Dosage: | Adult male Sprague–Dawley rats (275-300 g)[4] | | Administration: | Intraperitoneal injection | | Result: | Produces prominent dopamine D1 receptor agonist effects in vivo |
| [IC 50]
D1 Receptor: 10 nM (IC50) |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|