| Identification | Back Directory | [Name]
Candoxatrilat | [CAS]
123122-54-3 | [Synonyms]
U 73967
UK-73967
Unii-7wu8Bz90th
Candoxatrilat
(UK 73967)
Candoxatrilat [usan:inn:ban]
4α-[[[1-[(S)-2-Carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl]carbonyl]amino]cyclohexane-1α-carboxylic acid
(1s,4s)-4-{1-[(2S)-2-carboxy-2-[(2-methoxyethoxy)methyl]ethyl]cyclopentaneamido}cyclohexane-1-carboxylic acid
Cyclohexanecarboxylic acid, 4-(((1-((2S)-2-carboxy-3-(2-methoxyethoxy)propyl)cyclopentyl)carbonyl)amino)-, cis- | [Molecular Formula]
C20H33NO7 | [MDL Number]
MFCD00865966 | [MOL File]
123122-54-3.mol | [Molecular Weight]
399.481 |
| Chemical Properties | Back Directory | [Melting point ]
108.5-109.1° | [alpha ]
D +1.4° (c = 1 in methanol) | [Boiling point ]
642.1±55.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [pka]
4.32±0.11(Predicted) |
| Hazard Information | Back Directory | [Uses]
Antihypertensive. | [Definition]
ChEBI: Candoxatrilat is a dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP, neprilysin, EC 3.4.24.11), it is used as its 2,3-dihydro-1H-inden-5-yl ester prodrug in the treatment of chronic heart failure. It has a role as an EC 3.4.24.* (metalloendopeptidase) inhibitor. It is a dicarboxylic acid and a dicarboxylic acid monoamide. |
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