| Identification | Back Directory | [Name]
GIGAVLKVLTTGLPALISWIKRKRQ-OH | [CAS]
123168-46-7 | [Synonyms]
MELITTIN
MELITTIN (FREE ACID)
GIGAVLKVLTTGLPALISWIKRKRQ-OH
GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN: GIGAVLKVLTTGLPALISWIKRKRQQ | [Molecular Formula]
C131H228N38O32 | [MDL Number]
MFCD00080195 | [MOL File]
123168-46-7.mol | [Molecular Weight]
2847.45 |
| Hazard Information | Back Directory | [Uses]
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2]. | [in vivo]
Melittin (intraperitoneal inoculation) increases 13,14-dihydro-15-keto-PGE2 levels in peripheral blood of mice[1]. | [References]
[1] Hassid A, Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977. PMID:928951
[2] Memariani H, Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526. DOI:10.1007/s00253-020-10701-0 |
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