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12321-44-7

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12321-44-7 Structure

12321-44-7 Structure
IdentificationBack Directory
[Name]

CALCITONIN (PORCINE)
[CAS]

12321-44-7
[Synonyms]

ba46534
calcitare
pigcalcitonin
calcitonin(pig)
calcitonin(swine)
porcinecalcitonin
thyrocalcitonin(pig)
CALCITONIN (PORCINE)
THYROCALCITONIN PORCINE
pigalpha-thyrocalcitonin
alpha-thyrocalcitonin(pig)
alpha-thyrocalcitonin(porcine)
CALCITONIN (PORCINE) USP/EP/BP
H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Ser-Ala-Tyr-
CSNLSTCVLSAYWRNLNNFHRFSGMGFGPETP-NH2 (DISULFIDE BRIDGE: 1-7)
CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-SER-ALA-TYR-TRP-ARG-ASN-LEU-ASN-ASN-PHE-HIS-ARG-PHE-SER-GLY-MET-GLY-PHE-GLY-PRO-GLU-THR-PRO-NH2
H-CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-SER-ALA-TYR-TRP-ARG-ASN-LEU-ASN-ASN-PHE-HIS-ARG-PHE-SER-GLY-MET-GLY-PHE-GLY-PRO-GLU-THR-PRO-NH2
CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-SER-ALA-TYR-TRP-ARG-ASN-LEU-ASN-ASN-PHE-HIS-ARG-PHE-SER-GLY-MET-GLY-PHE-GLY-PRO-GLU-THR-PRO-NH2 PORCINE
H-CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-SER-ALA-TYR-TRP-ARG-ASN-LEU-ASN-ASN-PHE-HIS-ARG-PHE-SER-GLY-MET-GLY-PHE-GLY-PRO-GLU-THR-PRO-NH2 (DISULFIDE BRIDGE: 1-7)
CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-SER-ALA-TYR-TRP-ARG-ASN-LEU-ASN-ASN-PHE-HIS-ARG-PHE-SER-GLY-MET-GLY-PHE-GLY-PRO-GLU-THR-PRO-NH2 (DISULFIDE BRIDGE: CYS1-CYS7)
Calcitonin (porcine) H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Ser-Ala-Tyr-Trp-Arg-Asn-Leu-Asn-Asn-Phe-His-Arg-Phe-Ser-Gly-Met-Gly-Phe-Gly-Pro-Glu-Thr-Pro-NH2 (Disulfide bond)
[EINECS(EC#)]

235-585-3
[Molecular Formula]

C159H232N46O45S3
[MDL Number]

MFCD00151681
[MOL File]

12321-44-7.mol
[Molecular Weight]

3604.02
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

XP3561000
[Toxicity]

mouse,LD50,oral,> 8units/kg (8units/kg),Drugs in Japan Vol. 6, Pg. 180, 1982.
Hazard InformationBack Directory
[Uses]

Calcitonin, porcine inhibits 1,25 (OH)2D3-stimulated porcine osteoclast differentiation. Calcitonin is a polypeptide hormone that can lower serum calcium by decreasing calcium reabsorption in the kidney and inhibiting osteoclastic bone resorption. Calcitonin, porcine can be used for research of hypercalcemia[1][2].
[References]

[1] Galvin RJ, et al. Calcitonin responsiveness and receptor expression in porcine and murine osteoclasts: a comparative study. Bone. 1998 Sep;23(3):233-40. DOI:10.1016/s8756-3282(98)00096-9
[2] Kammerman S, et al. Effect of porcine calcitonin on hypercalcemia in man. J Clin Endocrinol Metab. 1970 Jul;31(1):70-5. DOI:10.1210/jcem-31-1-70
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