| Identification | Back Directory | [Name]
Benzenemethanol, 3-(2-quinolinylmethoxy)- | [CAS]
123226-28-8 | [Synonyms]
Benzenemethanol, 3-(2-quinolinylmethoxy)- | [Molecular Formula]
C17H15NO2 | [MOL File]
123226-28-8.mol | [Molecular Weight]
265.31 |
| Chemical Properties | Back Directory | [Melting point ]
78-82 °C | [Boiling point ]
457.3±30.0 °C(Predicted) | [density ]
1.232±0.06 g/cm3(Predicted) | [solubility ]
DMF:11.0(Max Conc. mg/mL);41.46(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);18.85(Max Conc. mM)
Ethanol:11.0(Max Conc. mg/mL);41.46(Max Conc. mM)
PBS (pH: 7.2):0.14(Max Conc. mg/mL);0.53(Max Conc. mM) | [form ]
A solid | [pka]
14.27±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
CAY10789 is an antagonist of the cysteinyl leukotriene 1 (CysLT1) receptor (IC50 = 2.1 μM). | [Uses]
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1]. | [IC 50]
CysLT1: 2.8 ± 0.3 μM (IC50) | [References]
[1] Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529. DOI:10.1021/acs.jmedchem.1c01078 |
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