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Aladorian (ARM036) sodium is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian sodium is a ryanodine receptor (RyR2) blocker. Aladorian sodium is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia[1][2][3]. | [References]
[1] Thevis M, et al. Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls. J Pharm Biomed Anal. 2014 Dec;101:66-83. DOI:10.1016/j.jpba.2014.05.020
[2] Luo M, et al. Mechanisms of altered Ca2? handling in heart failure. Circ Res. 2013 Aug 30;113(6):690-708. DOI:10.1161/CIRCRESAHA.113.301651
[3] Kupatt C, et al. Ryanodine Receptors Matter for Cardiac Function in Duchenne Muscular Dystrophy: Stability First. J Am Coll Cardiol. 2021 Dec 14;78(24):2454-2456. DOI:10.1016/j.jacc.2021.10.012 |
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