| Identification | Back Directory | [Name]
3-Pyrrolidinecarboxamide, N-[(9-chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-N-(2-methylpropyl)-1-(phenylmethyl)- | [CAS]
1233923-95-9 | [Synonyms]
A457
A-457
A 457
3-Pyrrolidinecarboxamide, N-[(9-chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-N-(2-methylpropyl)-1-(phenylmethyl)- | [Molecular Formula]
C26H33ClN2O3 | [MOL File]
1233923-95-9.mol | [Molecular Weight]
457 |
| Hazard Information | Back Directory | [Description]
A457 is a prokineticin receptor antagonist. | [Uses]
A457 is a prokineticin receptor PKR2 antagonist, with an IC50 of 102 nM. A457 can rescue the cell surface expression and function of P290S PKR2, but not W178S and G234D PKR2[1]. | [References]
[1] Dan-Na Chen, et al. Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking. J Biol Chem. 2014 May 30;289(22):15518-26. DOI:10.1074/jbc.M114.556381 |
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