| Identification | Back Directory | [Name]
FFN102 | [CAS]
1234064-11-9 | [Synonyms]
FFN102
FFN102 (Mini 102)
FFN102 >=98% (HPLC)
FFN-102 (trifluoroacetate salt) | [Molecular Formula]
C13H11ClF3NO5 | [MOL File]
1234064-11-9.mol | [Molecular Weight]
353.678 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml | [form ]
A crystalline solid | [color ]
white to light brown | [InChI]
1S/C11H10ClNO3.C2HF3O2/c12-8-4-7-6(1-2-13)3-11(15)16-10(7)5-9(8)14;3-2(4,5)1(6)7/h3-5,14H,1-2,13H2;(H,6,7) | [InChIKey]
OGHPXKAKVMJGQH-UHFFFAOYSA-N | [SMILES]
FC(F)(F)C(O)=O.NCCC(C1=CC(Cl)=C(O)C=C1O2)=CC2=O |
| Hazard Information | Back Directory | [Description]
FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). It is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals. It can also be used to monitor dopamine exocytosis. It has a pKa of 6.2 and displays pH-dependent excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values. The emission spectrum of FFN-102 is pH-independent at 453 nm, but the intensity of emission is pH-dependent with a higher intensity at a pH of 7.4. FFN-102 inhibits DAT (13.6% at a concentration of 10 μM) and the serotonin (5-HT) receptor subtype 5-HT2c (Ki = ~3 μM) but does not bind to 37 other central nervous system receptors and transporters, including dopamine receptors, up to a concentration of 10 μM. | [Uses]
FFN-102 trifluoroacetate is an analogue of biogenic neurotransmitters. FFN-102 trifluoroacetate is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals[1]. | [References]
[1] Liu X, et al. A Dual Functional Electroactive and Fluorescent Probe for Coupled Measurements of Vesicular Exocytosis with High Spatial and Temporal Resolution. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2366-2370. DOI:10.1002/anie.201611145 |
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