| Identification | Back Directory | [Name]
Benzenesulfonamide, 5-chloro-2-fluoro-4-[2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-2-yl- | [CAS]
1235406-03-7 | [Synonyms]
5-Chloro-2-fluoro-4-[2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
5-chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Benzenesulfonamide, 5-chloro-2-fluoro-4-[2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-2-yl-
acute,Na channels,inhibit,chronic,voltage,channel,Na+ channels,Sodium Channel,PF05186462,Inhibitor,Nav1.7,pain,PF-05186462,PF 05186462,sodium | [Molecular Formula]
C19H10ClF4N5O3S2 | [MDL Number]
MFCD33029284 | [MOL File]
1235406-03-7.mol | [Molecular Weight]
531.89 |
| Chemical Properties | Back Directory | [Boiling point ]
649.9±65.0 °C(Predicted) | [density ]
1.629±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.50±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain[1]. | [References]
[1] Jones HM, et, al. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels. Clin Pharmacokinet. 2016 Jul;55(7):875-887. DOI:10.1007/s40262-015-0365-0 |
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