| Identification | Back Directory | [Name]
rac BHFF | [CAS]
123557-91-5 | [Synonyms]
BHFF
rac BHFF
(R,S)-BHFF
rac BHFF >=98% (HPLC)
RACBHFF;RAC-BHFF;RAC BHFF
5,7-Di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one
5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
2(3H)-Benzofuranone, 5,7-bis(1,1-dimethylethyl)-3-hydroxy-3-(trifluoromethyl)-
5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl) -2(3H)-benzofuranone, 5,7-Di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one | [Molecular Formula]
C17H21F3O3 | [MDL Number]
MFCD03764148 | [MOL File]
123557-91-5.mol | [Molecular Weight]
330.34 |
| Chemical Properties | Back Directory | [Melting point ]
83 °C(Solv: heptane (142-82-5)) | [Boiling point ]
322.1±42.0 °C(Predicted) | [density ]
1.232±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
9.42±0.20(Predicted) | [color ]
white to beige | [InChI]
1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 | [InChIKey]
RVNOANDLZIIFHB-UHFFFAOYSA-N | [SMILES]
CC(C)(C)c1cc(c2OC(=O)C(O)(c2c1)C(F)(F)F)C(C)(C)C |
| Hazard Information | Back Directory | [Uses]
rac BHFF is a positive allosteric modulator of GABAB receptors. | [Biological Activity]
Potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active. | [in vivo]
rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice[1].
rac-BHFF (3, 10, 30 and 100 mg/kg, p.o.) reverses SIH and high significance was reached for 100 mg kg 1 (P<0.001)[1].
| Animal Model: | Male NMRI mice (20-25?g)[1]. | | Dosage: | 3, 10, 30 or 100?mg/kg. | | Administration: | P.O.. | | Result: | Significantly increased the LRR effects of a subthreshold dose of baclofen at doses of 3?mg/kg and above. |
| [storage]
Store at +4°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|