| Chemical Properties | Back Directory | [Melting point ]
103-104 °C | [Boiling point ]
837.840±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.312±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
6.222±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
Antimalarial agent 38 (Compound 1) exhibits activity against antiplasmodial, which inhibits Plasmodium falciparum D6 strain, chloroquine-sensitive Thai strain and chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model[1]. | [References]
[1] Auffret G, et al., Synthesis and antimalarial evaluation of a series of piperazinyl flavones. Bioorg Med Chem Lett. 2007 Feb 15;17(4):959-63. DOI:10.1016/j.bmcl.2006.11.051 |
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