| Identification | Back Directory | [Name]
Ammonium 2-aminoethane-1,1-disulfonic acid hydrate, min. 95% | [CAS]
1235825-84-9 | [Synonyms]
Ammoium2-aminoethane-1,1-disulfonicacidhydrate
Ammonium 2-aminoethane-1, 1-disulfonic acid hydrate
Ammonium 2-aminoethane-1,1-disulfonic acid hydrate, min. 95% | [Molecular Formula]
C2H10N2O6S2 | [MDL Number]
MFCD28411846 |
| Questions And Answer | Back Directory | [Uses]
This di-sulfonated building block is recommended for post-synthetic water-solubilization of hydrophobic, molecules for applications in biological media, especially organic dyes, fluorophores, azo dyes, bodipy, coumarin and xanthene dyes. This includes organic supramolecular compounds such as cryptophanes, through aminolysis reactions of activated esters, activated carbamates (or carbonates) and isothiocyanates. Such reactions can be performed either in aqueous media (Schotten-Baumann conditions), or in anhydrous organic media (by converting this di-sulfonated taurine analog into the corresponding tributylammonium or tetrabutylammonium salt). Such methodology is also applicable for sulfonation of biomolecules such as peptides and nucleic acids, for fine-tuning their net electric charge.
A further derivatization of this unusual amine with 3-azidopropanoic acid, 3-mercaptopropanoic acid, or 4-pentynoic acid, provides a di-sulfonated linker that is reactive in either “click” reactions (1,3-dipolar cycloadditions), SNAr or Sonogashira cross-couplings.
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