| Hazard Information | Back Directory | [Uses]
8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC50 value of 121 nM[1][2]. | [References]
[1] D C Zeldin, et al. Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem. 2001 Sep 28;276(39):36059-62. DOI:10.1074/jbc.R100030200
[2] Y Zhang, et al. EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2430-40. DOI:10.1152/ajpheart.2001.280.6.H2430 |
|
|