| Identification | Back Directory | [Name]
Almokalant | [CAS]
123955-10-2 | [Synonyms]
H 234?/09
Almokalant
Benzonitrile, 4-[3-[ethyl[3-(propylsulfinyl)propyl]amino]-2-hydroxypropoxy]- | [Molecular Formula]
C18H28N2O3S | [MDL Number]
MFCD00864746 | [MOL File]
123955-10-2.mol | [Molecular Weight]
352.49 |
| Hazard Information | Back Directory | [Uses]
Almokalant is a class III antiarrhythmic agent, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current. | [in vivo]
Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats[1]. | [storage]
Store at -20°C | [References]
[1] Wellfelt K, et al. Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species. Reprod Toxicol. 1999 Mar-Apr;13(2):93-101. DOI:10.1016/s0890-6238(98)00066-5 |
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