| Identification | Back Directory | [Name]
methyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate | [CAS]
1239588-09-0 | [Synonyms]
Tos-PEG4-methyl ester
Tos-PEG3-C2-methyl ester
methyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate | [Molecular Formula]
C17H26O8S | [MDL Number]
MFCD28967602 | [MOL File]
1239588-09-0.mol | [Molecular Weight]
390.45 |
| Hazard Information | Back Directory | [Description]
Tos-PEG4-methyl ester is a PEG linker with tosyl and methyl ester moieties. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound. Methyl ester can be hydrolyzed under strong basic condition. | [Uses]
Tos-PEG3-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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