| Identification | Back Directory | [Name]
PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN& | [CAS]
1240-15-9 | [Synonyms]
Unii-70bo17yr03
Propiomazine HCl
PROPIOMAZINE CHLORIDE)
UGVNGSMLNPWNNA-UHFFFAOYSA-N
PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN&
PROPIONYLPROMAZINE HYDROCHLORIDE VETRANA
1-Propanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-, monohydrochloride
Propiomazine D6 hydrochlorideQ: What is
Propiomazine D6 hydrochloride Q: What is the CAS Number of
Propiomazine D6 hydrochloride Q: What is the storage condition of
Propiomazine D6 hydrochloride Q: What are the applications of
Propiomazine D6 hydrochloride | [Molecular Formula]
C20H25ClN2OS | [MDL Number]
MFCD01696560 | [MOL File]
1240-15-9.mol | [Molecular Weight]
376.94 |
| Hazard Information | Back Directory | [Uses]
Propiomazine hydrochloride is an orally active antihistamine agent with sedative effects. Propiomazine hydrochloride can be used in the research of insomnia[1][2]. | [Brand name]
Largon (Baxter Healthcare). | [in vivo]
Propiomazine (0.2 mg/kg, nasal administration, rats) hydrochloride is quickly absorbed, followed by rapid reduction of the plasma concentrations[3].
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) hydrochloride protects rats against CCl4-induced hepatic injury[4].
Propiomazine (0.31-20 mg/kg, i.v.) hydrochloride increases plasma prolactin concentrations in rats[5].
| [References]
[1] B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42. DOI:10.1159/000195848
[2] Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037. PMID:34590703
[3] C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224.
[4] F T Serratoni, et al. Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study. Arch Pathol. 1969 Jan;87(1):46-51. PMID:5782435
[5] Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9. DOI:10.3181/00379727-178-42049 |
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