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124020-62-8

124020-62-8 Structure

124020-62-8 Structure
IdentificationBack Directory
[Name]

85548e
[CAS]

124020-62-8
[Synonyms]

85548e
U85548e
U-85548e
U 85548e
L-Valine, L-valyl-L-seryl-L-glutaminyl-L-asparaginyl-(2S,4S,5S)-5-amino-4-hydroxy-7-methyl-2-(1-methylethyl)octanoyl-L-isoleucyl-
[Molecular Formula]

C40H73N9O12
[MOL File]

124020-62-8.mol
[Molecular Weight]

872.08
Chemical PropertiesBack Directory
[Boiling point ]

1280.9±65.0 °C(Predicted)
[density ]

1.203±0.06 g/cm3(Predicted)
[pka]

3.38±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.
[References]

[1] HIV protease (HIV PR) inhibitor structure‐activity‐selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral?…
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