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1240305-17-2

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1240305-17-2 Structure

1240305-17-2 Structure

Identification	Back Directory
[Name] SGL5213
[CAS] 1240305-17-2
[Synonyms] SGL5213 SGL-5213,SGL5213 3-Butenamide, N-[2-[[2-(dimethylamino)ethyl]amino]-1,1-dimethyl-2-oxoethyl]-4-[4-[[5-β-D-glucopyranosyl-4-methoxy-2-(1-methylethyl)phenyl]methyl]phenyl]-2,2-dimethyl-, (3E)-
[Molecular Formula] C37H55N3O8
[MDL Number] MFCD32067901
[MOL File] 1240305-17-2.mol
[Molecular Weight] 669.85

Chemical Properties	Back Directory
[Boiling point ] 871.2±65.0 °C(Predicted)
[density ] 1.182±0.06 g/cm3(Predicted)
[pka] 13.32±0.70(Predicted)

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[Uses] SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. SGL5213 has potential to treat type 2 diabetes treatment[1].
[References] [1] Kuroda S, et al. Discovery of potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor SGL5213 for type 2 diabetes treatment. Bioorg Med Chem. 2019 Jan 15;27(2):394-409. DOI:10.1016/j.bmc.2018.12.015

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