| Identification | Back Directory | [Name]
5(2H)-Isoxazolone, 4-[(3-methoxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-3-phenyl- | [CAS]
1241046-32-1 | [Synonyms]
QM295
5(2H)-Isoxazolone, 4-[(3-methoxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-3-phenyl- | [Molecular Formula]
C17H13NO4 | [MOL File]
1241046-32-1.mol | [Molecular Weight]
295.29 |
| Chemical Properties | Back Directory | [Boiling point ]
456.5±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-7.70±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress[1]. | [in vivo]
QM295 (50 μM, 30 min) has the accumulation of an ERO1α form with lower mobility in vivo[1]. | [References]
[1] Jaime D Blais, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003. DOI:10.1074/jbc.M110.126599 |
|
|